内质网压力响应相关的蛋白质降解
DOI:
作者:
作者单位:

齐鲁工业大学生物工程学院;山东大学生命科学学院微生物技术国家重点实验室,齐鲁工业大学生物工程学院,齐鲁工业大学生物工程学院;山东大学生命科学学院微生物技术国家重点实验室,山东大学生命科学学院微生物技术国家重点实验室

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学基金(31370135), 山东大学基本科研业务费专项资金(2015CJ005)和山东省农业科技成果转化资金(2014-45)资助项目


Protein Degradation Related to Endoplasmic Reticulum Stress
Author:
Affiliation:

Bioengineering Institute,Qilu University of Technology,Jinan;State Key Laboratory of Microbial Technology,School of Life Sciences,Shandong University,Jinan,Bioengineering Institute,Qilu University of Technology,Jinan,Bioengineering Institute,Qilu University of Technology,Jinan;State Key Laboratory of Microbial Technology,School of Life Sciences,Shandong University,Jinan,State Key Laboratory of Microbial Technology,School of Life Sciences,Shandong University,Jinan

Fund Project:

This work was supported by grants from The National Natural Science Foundation of China (31370135), Fundamental Research Funds of Shandong University (2015CJ005) and Shandong Reseach Funds for Transfer of Agricultural Technological Achievements (2014-45)

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    内质网相关蛋白质降解途径(ERAD),即蛋白质分泌过程中错误折叠或未折叠的蛋白质在内质网中被识别并逆向运输到细胞质经聚泛素化后由蛋白酶体降解的过程.自从发现该途径后对其机制的阐明一直处于不断探索的阶段.近年来,对ERAD底物识别、逆向运输和泛素化新组分的发现以及新技术的应用,使得该途径的具体分子机制更加清晰.本文全面梳理并综述了内质网应激响应、ERAD降解过程与机理的最新进展,并对模式蛋白底物和最新研究方法进行了总结,以期展示该领域的研究概况.

    Abstract:

    Endoplasmic reticulum associated degradation (ERAD) is a mechanism, which recognizes misfolded and unfolded proteins of the ER and retrotranslocates them into the cytoplasm for degradation by the ubiquitin-protesome machinery. Since it was discovered, many researches have conducted to contribute to understanding the mechanism of this conserved pathway. Recently, with the significant progresses in identification of new components revolved in substrate recognition, retrotranslocation and ubiquitylation, as well as the development of new techniques in this area, the specific molecular mechanism of ERAD becomes more clear. The recent progress in the ER stress response and the roles of the components related to ERAD process are summarized with focuses on their molecular mechanisms to provide an overview of this field. Also, the model ERAD substrates and the novel strategies recently developed are included.

    参考文献
    相似文献
    引证文献
引用本文

闫孟节,侯运华,吕珊珊,钟耀华.内质网压力响应相关的蛋白质降解[J].生物化学与生物物理进展,2016,43(6):539-549

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2015-11-02
  • 最后修改日期:2016-03-24
  • 接受日期:2016-03-29
  • 在线发布日期: 2016-06-21
  • 出版日期: 2016-09-20