1. 湖南农业大学;2. 中国科学院深圳先进技术研究院(SIAT),湖南农业大学,中国科学院深圳先进技术研究院(SIAT),中国科学院深圳先进技术研究院(SIAT)
国家自然科学基金(81571445)和深圳市基础研究基金(JCYJ20150521094519488)资助项目
1. Hunan Agricultural University; 2.Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences(SIAT),Hunan Agricultural University,Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences(SIAT),Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences(SIAT)
This work was supported by grants from The National Natural Science Foundation of China (81571445) and Shenzhen Research Foundation for Basic Research (JCYJ20150521094519488)
子痫前期是一种非常严重的妊娠疾病,主要症状有高血压、蛋白尿、内皮功能障碍、肾小球血管内皮细胞增生以及滋养层细胞浸润不足等,动物模型是研究本病发病机理与开发诊治手段的主要工具.长期以来,针对子痫前期主要症状已经建立了多种动物模型,但不同的动物模型各有优缺点,至今仍没有一个理想的子痫前期动物模型,这也是子痫前期病因不明和缺乏有效治疗手段的主要原因之一.本文就已有的模型进行了归纳总结,旨在为不同研究需要而选择合适的模型,并为开发更为理想的子痫前期动物模型提供参考.
Preeclampsia (PE) is a severe pregnancy syndrome with multi-organ vascular dysfunction and classical symptoms, such as, maternal hypertension, proteinuria, glomerular endotheliosis and insufficient trophoblastic invasion. Although quite bit of animal models have been established for PE study, different animal models have both advantages and disadvantages. To date, there is still no one ideal animal model for PE study. This is also the reason that the etiology of PE is still unknown, and no effective treatments are available for PE. In the light of providing references for selecting the right animal model for investigations and establishing ideal animal models, we summarized the characteristic of different animal models for PE in this review.
肖仲琳,杨青,张键,范秀军.子痫前期动物模型的研究进展[J].生物化学与生物物理进展,2016,43(6):563-569
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