Oncogene induced cell senescence is an important tumor suppressor mechanism in vivo and in vitro. Ras is one of the most frequently mutant oncogene in human cancers. However, Ras induced cell transformation and malignization happened sometimes even under the supervision of OIS, which implicated Ras may obtained some pathways to bypass OIS. This article took Ras signal pathway as the main clue, to summarize the key molecules involved in OIS progression induced by Ras and some potential OIS overcome mechanism of Ras.