Kunming University of Science and Technology,Yunnan Eryuan County, the station right town of animal husbandry and veterinary,Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College,Shanghai Jiaotong University,Kunming University of Science and Technology,Kunming University of Science and Technology

This work was supported by a grant from the National Natural Science Foundation of China (31360619 and 81660338), the Natural Science Foundation of Yunnan Province (2013FB032), and the China Postdoctoral Science Foundation (2014M562672 and 2015T81138)