巨噬细胞胆固醇转运相关蛋白研究进展

首页 > 过刊浏览>2017年第44卷第2期 >139-147

巨噬细胞胆固醇转运相关蛋白研究进展
DOI:
                        
CSTR:
                        
作者:
                        
作者单位:南华大学医学院组织学与胚胎学教研室,南华大学医学院组织学与胚胎学教研室,南华大学医学院卓越医师班,南华大学医学院卓越医师班,南华大学,南华大学医学院组织学与胚胎学教研室
作者简介:
通讯作者:
中图分类号:
基金项目:国家自然科学基金(81670401)，湖南省自然科学基金项目(2016JJ6133)，南华大学大学生研究性学习和创新性实验计划(2016NH053XJXZ)，南华大学“蒸湘学者计划”(Xiangyang Tang)资助项目

Advances of Proteins Mediated Cholesterol Transport in Macrophages

Author:

Affiliation:

Department of Histology and Embryology, University of South China,Department of Histology and Embryology, University of South China,Class of Excellent doctor, University of South China,Class of Excellent doctor, University of South China,University of South China,Department of Histology and Embryology, University of South China

Fund Project:

This work was supported by grants from The National Natural Science Foundation of China (81670401), The Natural Science Foundation of Hunan Province (2016JJ6133), College Students' Research Learning and Innovative Experiment Plan in University of South China (2016NH053XJXZ) and the Zhengxiang Scholar (Xiangyang Tang) Program in University of South China

摘要

图/表

访问统计

参考文献

相似文献

引证文献

资源附件

文章评论

摘要:

动脉粥样斑块中泡沫细胞的形成与巨噬细胞胆固醇的转运密切相关，巨噬细胞胆固醇转运是胆固醇逆转运中的一个重要过程，它可清除外周组织过多的胆固醇，对维持细胞内胆固醇稳定、延缓动脉粥样硬化的发生发展有着重要意义．这个过程涉及到许多转运相关蛋白的作用，如三磷酸腺苷结合盒转运体A1/G1、载脂蛋白A-Ⅰ、胆固醇脂转运蛋白、卵磷脂胆固醇酰基转移酶等．本文就巨噬细胞胆固醇转运过程中相关蛋白的作用做一综述，以期为动脉粥样硬化相关疾病的防治研究提供新的思路．

Abstract:

The formation of foam cells in atherosclerotic plaques is closely related to the cholesterol transport of macrophages, which is an important process in reverse cholesterol transport. The cholesterol transport is key procedure for eliminating excess cholesterol from peripheral tissue, maintaining cholesterol homeostasis and delaying the development of atherosclerosis. The cholesterol transport of macrophages is mediated by multiple proteins, such as ATP binding cassette transporter A1/G1, apolipoprotein A-Ⅰ, cholesteroyl ester transfer protein and lecithin: cholesterol acyltransferase. This review focuses on the current views on cholesterol transport process in macrophages and various functions of transporter proteins, in order to provide the new therapeutic ways for atherosclerosis-related diseases.

参考文献

相似文献

引证文献

引用本文

欧含笑,郭冰冰,田期先,蒋湘,唐朝克,莫中成.巨噬细胞胆固醇转运相关蛋白研究进展[J].生物化学与生物物理进展,2017,44(2):139-147

复制

文章指标

点击次数:
下载次数:
HTML阅读次数:
引用次数:

历史

收稿日期:2016-09-14
最后修改日期:2017-01-02
接受日期:2017-01-17
在线发布日期: 2017-02-22
出版日期: 2017-02-20

引用本文

分享

文章指标

历史