北京大学膜生物学国家重点实验室,北京大学膜生物学国家重点实验室,北京大学膜生物学国家重点实验室,北京大学膜生物学国家重点实验室
国家重大研发计划(2016YFA0500401),国家自然科学基金(31630035,81370203,81461148026,31327901)和北京市科技计划(Z141100000214006)资助项目
State Key Laboratory of Membrane Biology,Peking University,State Key Laboratory of Membrane Biology,Peking University,State Key Laboratory of Membrane Biology,Peking University,State Key Laboratory of Membrane Biology,Peking University
This study was supported by the State Major Research and Development Program (2016YFA0500401), National Natural Science Foundation of China (31630035, 81370203, 81461148026, and 31327901) and the Project of Beijing Municipal Science and Technology Commission (Z141100000214006)
钙离子是最广泛存在的细胞内信使,调控着几乎所有生命过程。最近的结构生物学研究解析了很多不同种类的钙离子通道在不同开放-关闭状态下的近原子分辨率结构。有关进展揭示了这些通道的分子组成、动态活动、生理功能、调控修饰的分子基础,为阐明钙信号转导和相关疾病的微观机制提供了理论基础.
Ca2+ is a universal intracellular messenger playing important roles in nearly all biological processes. Recent studies of structural biology have resolved near-atom-resolution structure of many Ca2+ permeable ion channels in their different open/close states. These advances have revealed the molecular mechanisms for the channel construction, operation, function and regulation, and provide a fundamental basis for understanding the process of Ca2+ signaling and related diseases.
范雪新,杨磊,项斌,王世强.钙离子通道蛋白的研究进展[J].生物化学与生物物理进展,2016,43(12):1129-1138
复制生物化学与生物物理进展 ® 2025 版权所有 ICP:京ICP备05023138号-1 京公网安备 11010502031771号