The central dogma of molecular biology describes the flow of genetic information within the biological system. According to the classical central dogma, RNA can only play its role in life through translation. With the development of molecular biology, rapidly growing evidence shows that RNAs perform a vast array of functions within organisms even without translation. Moreover, RNA can fold into different types aside from linear RNA. Here, we summarized the four forms of RNA for their post transcriptional fate: non-translation, part-translation, de novo-translation and over-translation. Non-translation means the RNAs can’t be translated to proteins as many non-coding RNAs do. Part-translation describes a phenomenon that the RNA can’t translate into a peptide chain using all the information as a template, but only a part of it. Whereas the de novo-translation refers to the classical translation process. Over-translation means the RNA can encode a protein using more than their own genetic information, which only occurs in circular RNAs. The diversity of RNA’s fate extends largely our understanding of translation above the classical central dogma. Further understanding of the fate of RNA post transcription will put forward more challenging demand on the research for the functions of RNA, and meanwhile, will also present the potential solutions for comprehensive understanding of the functions of RNA.