BK通道的生物物理特性与门控及其最新研究进展
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内蒙古师范大学生命科学与技术学院,清华大学航天航空学院生物力学与医学工程研究所,四川理工学院 自动化与信息学院, 614000,清华大学航天航空学院生物力学与医学工程研究所,名古屋大学医学院,清华大学生物力学与医学工程研究所

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国家自然科学基金(11772175,11472159)与教育部重点实验室(CQKLBST-2017-006)资助项目


The Research Progresses of Biophysical Properties and Gating Mechanisms of BK Channel
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School of life science and technology, Inner Mongolia Normal University. Hohhot, 010020,Institute of Biomechanics and Medical Engineering, Department of Engineering Mechanics, Tsinghua University, Beijing, 100084,School of Automation and Information Engineering, Sichuan University of Science and Engineering, Zigong, 614000,Institute of Biomechanics and Medical Engineering, Department of Engineering Mechanics, Tsinghua University, Beijing, 100084,Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan,1Institute of Biomechanics and Medicine Engineering, Tsinghua University

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This work was supported by grants from The National Natural Science Foundation of China (11772175, 11472159) and Key Laboratory Projects of The Ministry of Education (CQKLBST-2017-006)

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    摘要:

    BKCa通道是细胞膜上受Ca2+ 和膜电位双重调控的离子通道,其与细胞信号系统偶联并发挥着重要作用,该通道高度表达于高等动物的多种组织.最近的研究证实,在心肌细胞膜上存在力敏感BK通道并参与了心脏收缩与舒张的调控.本文将介绍BK通道与L-型钙通道功能上的耦合,心肌细胞质膜力敏感BK通道门控和功能的研究,以及对基底刚度的响应.这有助于更好地理解力敏感离子通道相关心脏疾病的病理和生理学基础.

    Abstract:

    Large conductance Ca2+ activated potassium channels are regulated by both intracellular Ca2+ and membrane potential. BK channel couples membrane voltage with the intracellular signal system, that plays important roles for cellular functions. BK channel is widely and densely expressed in various tissues of many species. Recent studies have demonstrated that BK channel was expressed in cardiomyocytes and involved in the regulation of cardiac systolic and diastolic. In this work, we present some progress in the study of coupling between BK channel and L-type Ca2+ channel gating and the function of cardiomyocyte BK channels as well as the response to substrate stiffness. These reports will help to understand the pathophysiology of mechano-sensitive ion channel-associated heart diseases.

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吴榕,文宇桥,余洋,刘丝丝,Sokabe M,赵虎成. BK通道的生物物理特性与门控及其最新研究进展[J].生物化学与生物物理进展,2018,45(1):36-42

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历史
  • 收稿日期:2017-05-06
  • 最后修改日期:2017-11-15
  • 接受日期:2017-11-28
  • 在线发布日期: 2018-01-16
  • 出版日期: 2018-01-20