Neural control technology (NCT) could activate the function of the nervous system, alleviate neurological disease and improve the quality of life by importing electrical, magnetic, optical, acoustic and other physical factors to the neural circuits. The technology has been widely used in the research of life science and clinical diagnosis and treatment. Especially, low intensity focused ultrasound (LIFU) has the advantages of nondestructive, high penetration ability and spatial resolution, which is more suitable for the neural regulation as a safety physical stimulating factor. At the moment, research of LIFU in neural control has attracted much attention of scientific community. A large number of animal and human researches in neural control have been carried out and achieved gratifying results. In this paper, we review the progress of the LIFU regulation in central nervous system in the animals and human. Besides, the biophysical mechanism, security issues and future applications are also discussed. We hope this paper will provide a new insight to the research and application of neural regulation of LIFU.