沈阳师范大学 物理科学与技术学院,沈阳师范大学 物理科学与技术学院,沈阳师范大学 物理科学与技术学院,华中农业大学理学院,沈阳师范大学 物理科学与技术学院
国家自然科学基金(11604112),辽宁省自然科学基金(2015020715),沈阳师范大学优秀人才支持计划(BS201433),沈阳师范大学自主科研计划(L201514)和沈阳师范大学博士启动计划(51600209)资助项目
College of Physics Science and Technology, Shenyang Normal University,College of Physics Science and Technology, Shenyang Normal University,College of Physics Science and Technology, Shenyang Normal University,College of Science, Huazhong Agricultural University,College of Physics Science and Technology, Shenyang Normal University
This work was supported by grants from The National Natural Science Foundation of China (11604112), Liaoning Natural Science Foundation (2015020715), Shenyang Normal University Scientific Research Program (L201514), Doctor Start-up Fund of Shenyang Normal University (51600209), and Talent Support Program of Shenyang Normal University (BS201433)
全场光学相干层析成像技术(全场OCT)是研究早期胚胎形态发育的最理想成像设备,然而所采集图像难免受噪声干扰.这些噪声可模糊早期胚胎内不同组织结构的边界,从而给基于图像边界的结构划分带来干扰.为解决这一问题,本文运用中值滤波、维纳滤波、各向异性扩散算法处理全场OCT获得的早期胚胎图像,并运用信噪比、均方误差、峰值信噪比和边缘保留等指标评价图像处理效果.结果表明:经各向异性扩散算法处理的早期胚胎图像,可完整地保留原始图像信息,且边界最清晰,视觉效果最好.
The full-field optical coherence tomography (FF-OCT) is one of the best technologies to study the morphological development of the early embryo, while its images suffer from some noises. Due to the noises, the boundaries between the different organizations in the early embryo are ambiguous, which would cause interference of organization segmentation. To solve this problem, this paper processed full-field OCT images of early embryos with the median filter, wiener filter and anisotropic diffusion algorithm, and evaluated the noise reduction effect using the signal-to-noise ratio, the mean square error, peak signal to noise ratio and edge retention index. It was shown that early embryo images after noise reduction with anisotropic diffusion algorithm kept most of the original information with relatively clear boundaries. Therefore, anisotropic diffusion algorithm is suggested to be the best denoising method for FF-OCT imaging in terms of the visual effect.
王一鸣,王婷,于吉,张纾,田宁.早期胚胎全场OCT图像的边界去模糊研究[J].生物化学与生物物理进展,2018,45(10):1078-1082
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