广东医科大学,东莞市药物设计与制剂技术重点实验室,广东医科大学纳米药物制剂重点实验室;中国科学院深圳先进技术研究院,中国科学院健康信息学重点实验室,广东省纳米医药重点实验室,深圳癌症纳米技术重点实验室,中国科学院深圳先进技术研究院,中国科学院健康信息学重点实验室,广东省纳米医药重点实验室,深圳癌症纳米技术重点实验室,广东医科大学,东莞市药物设计与制剂技术重点实验室,广东医科大学纳米药物制剂重点实验室;中国科学院深圳先进技术研究院,中国科学院健康信息学重点实验室,广东省纳米医药重点实验室,深圳癌症纳米技术重点实验室,广东医科大学,东莞市药物设计与制剂技术重点实验室,广东医科大学纳米药物制剂重点实验室;中国科学院深圳先进技术研究院,中国科学院健康信息学重点实验室,广东省纳米医药重点实验室,深圳癌症纳米技术重点实验室,中国科学院深圳先进技术研究院,中国科学院健康信息学重点实验室,广东省纳米医药重点实验室,深圳癌症纳米技术重点实验室,广东医科大学,东莞市药物设计与制剂技术重点实验室,广东医科大学纳米药物制剂重点实验室,广东医科大学,东莞市药物设计与制剂技术重点实验室,广东医科大学纳米药物制剂重点实验室,中国科学院深圳先进技术研究院,中国科学院健康信息学重点实验室,广东省纳米医药重点实验室,深圳癌症纳米技术重点实验室
国家自然科学基金(21375141,81401509,81371679,21404115, 81401520,21701033),重要国际科技合作项目(2015DFH50230),广东省自然科学基金(2017A030313079,2017A030313726),东莞社会科技发展项目(2015108101019),中国博士后基金面上项目(2017M612803)和广东医科大学科研基金面上培育项目(M2016006)资助
Key Laboratory for Nanomedicine of Guangdong Medical University, Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Medical University; CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen,CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen,Key Laboratory for Nanomedicine of Guangdong Medical University, Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Medical University; CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen,Key Laboratory for Nanomedicine of Guangdong Medical University, Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Medical University; CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen,CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen,Key Laboratory for Nanomedicine of Guangdong Medical University, Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Medical University,Key Laboratory for Nanomedicine of Guangdong Medical University, Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Medical University,CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen
This work was supported by grants from The National Natural Science Foundation of China (21375141, 81401509, 81371679, 21404115, 81401520 and 21701033), Key International S&T Cooperation Project (2015DFH50230), Natural Science Foundation of Guangdong Province (2017A030313079, 2017A030313726), Dongguan Project on Social Science and Technology Development (2015108101019), Chinese Postdoctoral Project (2017M612803) and Science Foundation of Guangdong Medical University (M2016006)
刺激响应型纳米载体是通过对外界刺激响应而产生相应结构或理化性质变化的纳米智能载药体系,具有避免药物过早泄露,提高病灶药物浓度的特点,目前已成为肿瘤诊断和治疗领域的研究热点,广泛用于控制药物的呈递和释放.本文从温度、磁场、超声、光、pH等外源和内源刺激角度,阐述了智能响应型纳米载体近年来在肿瘤诊疗领域的研究进展.
Stimuli responsive nanocarriers as nano-intelligent drug delivery system could make corresponding change in structure and physicochemical properties for response to external stimulus.Take the advantages of avoiding premature drug release and improving the drug concentration in the lesion, they have become a focus in diagnosis and treatment of cancer and were widely used to control drug delivery and release.Based on the temperature, magnetic field, ultrasonic, light, pH and other endogenous and endogenous stimulus, we reviewed the recent research development of stimuli responsive nanocarriers in the field of tumor diagnosis and treatment in this paper.
田浩,赵鹏飞,郑明彬,马爱青,罗震宇,陈世春,鲁澄宇,蔡林涛.刺激响应型纳米载体在肿瘤诊疗中的研究进展[J].生物化学与生物物理进展,2018,45(6):593-600
复制生物化学与生物物理进展 ® 2024 版权所有 ICP:京ICP备05023138号-1 京公网安备 11010502031771号