Alzheimer’s disease (AD) is a complex multifactorial disease, characterized by progressive cognitive impairments and loss of memory. At present, there is no effective treatment for AD. The neurons differentiated from induced pluripotent stem cells (iPSCs) which are derived from AD patients have the relevant pathological manifestations of AD. Thus iPSCs is one of models for the study of the pathogenesis of AD and for finding the underlying drug target for AD. iPSCs can differentiate into different types of nerve cells to improve the symptoms of AD. The study of iPSCs in AD became an important issue. The advantages of iPSCs as a model in the pathological study of AD and the role of iPSCs in AD treatment were summarized in this article.