1.南华大学心血管疾病研究所,动脉粥样硬化学湖南省重点实验室,医学研究实验中心,衡阳 421001;2.南华大学医学院组织学与胚胎学教研室,衡阳 421001
国家自然科学基金资助项目(81770461)
1.Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province,Hengyang 421001,China;2.Department of Histolong and Embryology,University of South China,Hengyang 421001,China
This work was supported by a grant from The National Natural Science Foundation of China (81770461)
血浆载脂蛋白A-Ⅰ(apoA-Ⅰ)的水平与动脉粥样硬化(atherosclerosis,AS)性心血管疾病的风险呈负相关.ApoA-Ⅰ经载脂形成高密度脂蛋白(HDL), HDL通过促进胆固醇逆向转运(RCT),使细胞内的多余胆固醇流出.α螺旋是apoA-Ⅰ载脂的主要结构,在apoA-Ⅰ参与的胆固醇流出中具有重要作用.模拟α螺旋建立的apoA-Ⅰ模拟肽能通过不同方式发挥抗AS的作用.本文就α螺旋在胆固醇流出中的作用作一综述,以便进一步探索apoA-Ⅰ的结构对胆固醇流出的影响,为以apoA-Ⅰ为靶点防治AS提供理论基础.
Since the inverse relationship between the levels of apoA-Ⅰ in plasma and the risk of cardiovascular disease is derived from the atherosclerosis (AS). Lipid apoA-Ⅰ formation of high-density lipoprotein(HDL), which by promoting reverse cholesterol transport(RCT) helps cholesterol efflux. α-Helix plays an important role in cholesterol efflux, it’s the acceptor of lipid on apoA-Ⅰ. The mimic peptides of apoA-Ⅰ have similar structure with α-helix, and they can inhibit the development of AS by different ways. This review focuses on the effects of α-helix of apoA-Ⅰ in cholesterol efflux, in order to further explore the structure of apoA-Ⅰ influence on cholesterol efflux, aims at providing the new thought and therapy targeting for AS.
高嘉慧,莫中成,唐朝克. apoA-Ⅰ的α螺旋在胆固醇流出中的作用[J].生物化学与生物物理进展,2018,45(6):629-636
复制生物化学与生物物理进展 ® 2025 版权所有 ICP:京ICP备05023138号-1 京公网安备 11010502031771号