Mycobacteria tuberculosis (MTB) is the pathogen responsible for tuberculosis. It can exist in the infected-macrophages for a long time and trigger the disease when the appropriate conditions arise. The primary way to kill intracellular bacteria is via the oxygen-independent route. In this route, macrophages mainly rid themselves of parasites by autophagy where autophagosomes and lysosomes are fused into autophagolysosomes. However, MTB can resist to autophagy and avoid being killed by the immune system of host cells in several ways, thereby co-existing with the host. MicroRNAs (miRNA) are endogenous non-coding single-chain RNA molecules that can silence related genes expression in a post-transcriptional manner. They are crucial molecules for mediating inflammatory reactions between MTB and inflammatory cells. Recent studies found that MTB can induce the expression of certain specific miRNAs in macrophages and target genes related to autophagy and therefore inhibit triggering and progression of autophagy. This mechanism confers resistance to autophagy. The present review summarizes the role of miRNA in the resistance to autophagy by MTB.