Platelet circular RNA (platelet circRNA) is a kind of circular RNA molecules formed by RNA “back-splicing” and closing, which has stable structure, high abundance, and cellular and tissue specificity. Platelet circRNA can regulate intracellular network, and is closely related to the occurrence or progression of various diseases. Its difference in expression may make it to be ideal biomarker and therapeutic target. In recent years, research achievements on its production, regulation, biological characteristics, functions as well as its relationship with diseases have been made. Here we present a review of progress in platelet circRNA research.