1.Zhuhai Campus of Zunyi Medical University, Zhuhai 519040, China;2.Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zhuhai Campus of Zunyi Medical University, Zhuhai 519040, China;3.Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510640, China

This work was supported by grants from The National Natural Science Foundation of China(31560244), Science and Technology Cooperation Project of Guizhou Province(LH20157547),＂15851 Talent Elite Project＂of Zunyi City, Opening Project of Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine(ZYKL-2016K2), Opening Project of Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, South China University of Technology(FJ2015003)， Zunyi Medical University Project Fund of Graduate Research(ZYK009).