1.吉林大学第二医院心血管内科,长春 130012;2.吉林大学第二医院放射科,长春 130012
吉林省教育厅十三五科学技术研究项目(JJKH20180104KJ),吉林省财政厅卫生专项项目(JC20170125)和吉林省新型冠脉支架科技创新中心项目(JKFC2017250)资助
1.Department of cardiovascular medicine,Second Hospital of Jilin University;2.Department of Radiology,Second Hospital of Jilin University;3.Second Hospital of Jilin University;4.China
This work was supported by grants from Jilin Province Education Department Thirteenth Five Science And Technology Research Project(JJKH20180104KJ), Jilin Provincial Department of Finance Health Special Project(JC20170125) and Jilin Province New Coronary Stent Technology Innovation Center Funded Project(JKFC2017250)
热量限制(caloric restriction,CR)是指在不减少必需营养素摄入的情况下减少20%~40%的热量摄入. CR可通过由各种分子介导的氧化应激、炎症、程序性死亡、端粒体等机制,通过调节人及其他动物心血管老化的危险因素,进而减缓生理和病理状态下心血管老化进程. 本文通过对CR与心血管老化研究进展的系统阐述,探寻人类预防心血管老化的解决之道.
Caloric restriction (CR) refers to a 20%-40% reduction in caloric intake without reducing essential nutrient intake. CR can alleviate the cardiovascular aging process under physiological and pathological conditions by mainly mechanisms including oxidative stress, inflammation, programmed death and telomerewhich are mediated by sundry molecules as well as regulating the risk factors of cardiovascular aging in human and other animals. This paper systematically elaborates the research progress of CR and cardiovascular aging and explore the solution to prevent cardiovascular aging in humans.
凌浩,刘威武,侯秀伟,陈晓会,肖钰,闫会,宋春莉.热量限制与心血管老化的研究进展[J].生物化学与生物物理进展,2019,46(3):256-265
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