1.浙江工业大学材料科学与工程学院磁电功能材料研究所,杭州 310014;2.西北大学化学与材料科学学院,西安 710069;3.中国科学院国家纳米科学中心纳米生物效应与安全性重点实验室,北京 100190;4.河北科技大学生物科学与工程学院,石家庄 050018
国家自然科学基金(51602285),中国科协青年人才托举工程(2017QNRC001),清华大学先进材料教育部重点实验室开放基金(53220330118),中国博士后基金(2017M610838)和博士后创新人才支持计划(BX201600041)资助项目
1.Zhejiang University of Technology;2.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China
This work was supported by grants from The National Natural Science Foundation of China (51602285), Young Elite Scientist Sponsorship Program by CAST (2017QNRC001), Fund of Key Laboratory of Advanced Materials of Ministry of Education (53220330118), Postdoctoral Innovative Talent Support Program (BX201600041) and Postdoctoral Science Foundation of China (2017M610838)
磁性纳米颗粒具有独特的磁学性质,即在外加交变磁场下因产生磁滞释放热量,使其在生物医学领域,特别是肿瘤磁热疗,获得了广泛应用. 到目前为止,磁性纳米颗粒介导的磁热疗成为一种治疗癌症的有效手段,已进入临床三期实验. 因此,针对磁性纳米颗粒本身,优化设计尺寸、形貌、组分和表面修饰来提高其磁热性能,进而减小临床应用中的颗粒浓度来最小化毒副作用的研究,对肿瘤治疗及生物医药研究具有十分重要的意义. 本综述详述如何优化调制磁性纳米颗粒以提高其磁热性能,为高效、低毒的磁性纳米颗粒的设计提供了指导性的研究方向.
The application of magnetic nanoparticles in the biomedical field has widely utilized in recent years especially in magnetic-mediated hyperthermia for cancer treatment because of their unique magnetic properties, that is, the hysteresis loss induces heat under an alternating magnetic field. So far, the magnetic-mediated hyperthermia as a kind of effective means for the treatment of cancer, has entered the third phase of clinical trial. Therefore, in view of the magnetic nanoparticles itself, it has great significance to optimize size, morphology, composition and surface modification to improve their magnetic hyperthermia performance. So it can reduce the concentration of magnetic nanoparticles in clinical practice and minimize the side effects in tumor treatment. This review described in detail that how to optimize the modulation of magnetic nanoparticles to improve magnetic hyperthermia performances.
江小莉,王燕云,王英泽,余靓,刘晓丽.调制磁性纳米颗粒提高磁热性能的研究[J].生物化学与生物物理进展,2019,46(3):248-255
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