1.河北师范大学生命科学学院,石家庄 050024;2.河北省计量监督检测研究院,石家庄 050051
国家自然科学基金(31400857),河北省高等学校科学技术研究项目(BJ2017005)和河北省重点基础研究专项(18962401D)资助项目.
1.College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China;2.Institute of Metrology of Hebei Province, Shijiazhuang 050051, China
This work was supported by the grants from The National Natural Science Foundation of China (31400857), the Science and Technology Research Project for Colleges and Universities of Hebei Province (BJ2017005), and the Key Basic Research Project in Hebei Province (18962401D).
脑铁稳态对于维持脑的正常发育和控制细胞氧化应激水平具有重要作用. 大量研究已显示,脑铁稳态的失衡与阿尔茨海默病(Alzheimer’s disease,AD)的发病存在密切关系,但其机理尚需深入研究. 本文结合本实验室的研究结果,总结了脑铁代谢失衡参与AD病变的研究进展,重点讨论了脑铁增高与AD症状及细胞损伤的关系,及负责铁摄入、储存、释放和调控的几种铁代谢关键分子在AD中的表达变化,并展望了改善脑铁水平、调节铁代谢相关分子平衡、降低氧化应激等方法作为AD治疗策略的前景. 本文旨在为今后深入研究脑铁代谢及相关分子在AD病理过程中的作用,开发预防和治疗AD新药物提供参考.
Brain iron homeostasis plays an important role in maintaining normal brain development and controlling cellular oxidative stress. Accumulating studies have shown that the imbalance of brain iron homeostasis is closely involved in the pathogenesis of Alzheimer’s disease (AD). Here, we reviewed the research progress of the role of iron metabolism in the pathogenesis of AD, particularly focusing on the alterations of several key molecules responsible for cellular iron uptake, storage, release and regulation, and discussed potential therapeutic strategies for AD against the elevated brain iron and altered cellular iron metabolic pathways. This review may contribute to further studies focusing on the role of iron metabolism and related molecules in AD pathogenesis, and provide new insight for the development of AD drugs targeting these molecules.
徐永,张雅婷,李洁,洪钏,张欣韦,高国粉,常彦忠.脑铁代谢紊乱为阿尔茨海默病的治疗提供新靶点[J].生物化学与生物物理进展,2019,46(9):858-868
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