隧道纳米管——一种新的细胞间连接
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1)清华大学航天航空学院工程力学系,生物力学与医学工程研究所,北京100084;2.3)新疆大学机械工程学院,乌鲁木齐830046;3.2)Department of Human and Animal Physiology Fundamental Medicine and Biology Faculty, Kazan Federal University, Kazan 420008, Russia;4.1)清华大学航天航空学院工程力学系,生物力学与医学工程研究所,北京 100084

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Tel: 010-62782771, E-mail: zhaohc@mail.tsinghua.edu.cnTel: 86-10-62782771, E-mail: zhaohc@mail.tsinghua.edu.cn

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基金项目:

国家自然科学基金(12072176,12032014,11620101001, 11772175,12011530059)资助项目.


Tunneling Nanotubes—A New Form of Intercellular Junction
Author:
Affiliation:

1)Institute of Biomechanics and Medical Engineering, Department of Engineering Mechanics, School of Acrospace Engineering, Tsinghua University, Beijing 100084, China;2.3)School of Mechanical Engineering, Xinjiang University, Urumqi 830046, China;3.2)Department of Human and Animal Physiology Fundamental Medicine and Biology Faculty, Kazan Federal University, Kazan 420008, Russia

Fund Project:

This work was supported by grants from The National Natural Science Foundation of China (12072176, 12032014, 11620101001, 11772175, 12011530059).

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    摘要:

    细胞间通讯和物质交换是多细胞生物发育、组织修复和细胞生存的重要环节. 最近发现细胞间存在隧道纳米管(tunneling nanotubes,TNTs)连接,并以此进行长距离通讯. TNTs是一种细胞间长距离的物理连接,能够在相连的细胞之间实现远程、定向的通讯. 研究表明,不同细胞间TNTs在结构、形成机制和功能特性上存在相当大的差异. 尽管这一新的研究领域取得了进展,但仍迫切需要进一步探索. 本文综述TNTs的结构形态特征、生物功能、形成机制及其在疾病传播和疾病治疗中的应用前景,并讨论由TNTs介导的电耦联的研究现状.

    Abstract:

    Cell-to-cell communication is essential for the organization, coordination and development of multi-cellular systems. Intercellular communication and substance exchange are important links in the development, tissue repair and cell survival of multicellular organisms. Recently, it has been found that tunneling nanotubes (TNTs) connections are formed between cells for long-distance communication. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells. The proposed functions of TNTs are diverse and not well understood. It has been shown to include that there are considerable differences in the structure, formation process and functional properties of TNTs in cells of different types. Recent progress has been made in this new research field. However, the exact role of TNTs for intercellular communication and their impact on diseases are still uncertain, further research is urgently needed. The combined data from numerous laboratories indicate that some TNTs mediate a long-range communication to coordinate metabolism and signaling. This paper aims to describe the structure, morphology, characteristics and function of TNTs, the formation mechanism of TNTs and the application prospect of TNTs in disease transmission and disease treatment, and discusses the research advances of TNTs-mediated electrical coupling.

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孙艳丽,Aleksey Yakovlev,刘丝丝,赵虎成,冯西桥.隧道纳米管——一种新的细胞间连接[J].生物化学与生物物理进展,2021,48(11):1273-1281

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历史
  • 收稿日期:2020-12-08
  • 最后修改日期:2021-04-20
  • 接受日期:2021-04-27
  • 在线发布日期: 2021-11-23
  • 出版日期: 2021-11-20