首页 > 过刊浏览>2021年第48卷第12期 >1404-1413. DOI:10.16476/j.pibb.2021.0199
PDF HTML阅读 XML下载 导出引用 引用提醒
小胶质细胞极化与抑郁症关系的研究进展
作者:
作者单位:

1)桂林医学院广西脑与认知神经科学重点实验室，桂林541199;2)南华大学衡阳医学院生理学教研室，衡阳421001;3) 桂林医学院药学院，桂林 541199;4.1) 桂林医学院广西脑与认知神经科学重点实验室，桂林 541199;5.4) 桂林医学院附属第二医院，广西卫健委糖脂代谢紊乱重点实验室中心实验室，桂林 541199;6.5) 桂林医学院基础医学院生理学教研室，桂林 541199;7.6) 桂林医学院第二附属医院全科医学科，桂林 541199

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学基金（82060250）、广西科技计划项目（AD20238035）、湖南省自然科学基金（2019JJ50541）、广西脑与认知神经科学重点实验室开放项目（GKLBCN-20190105-02）和广西壮族自治区大学生创新创业培训项目（202010601050，202110601010）资助.


Research Progress on The Relationship Between Microglia Polarization and Depression
Author:
Affiliation:

1) Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical College, Guilin 541199, China;2) Department of Physiology, Hengyang Medical College, University of South China, Hengyang 421001, China;3) School of Pharmacy, Guilin Medical College, Guilin 541199, China;4) Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, Second Affiliated Hospital of Guilin Medical College, Guilin 541199, China;5) Department of Physiology, Basic Medical College, Guilin Medical College, Guilin 541199, China;6.6) General Practice Department, Second Affiliated Hospital of Guilin Medical College, Guilin 541199, China

Fund Project:

This work was supported by grants from The National Natural Science Foundation of China (82060250), the Guangxi Science and Technology Plan Project (AD20238035), the Natural Science Foundation of Hunan Province (2019JJ50541), the Open Project of Guangxi Key Laboratory of Brain and Cognitive Neuroscience (GKLBCN-20190105-02) and the Guangxi Zhuang Autonomous Region Students’ Innovation and Entrepreneurship Training Program of China (202010601050, 202110601010).

  • 摘要
    • |
  • 图/表
    • |
  • 访问统计
    • |
  • 参考文献
    • |
  • 相似文献
    • |
  • 引证文献
    • |
  • 资源附件
    • |
  • 文章评论
    摘要:

    小胶质细胞控制着中枢神经系统主要的免疫功能，在各种精神疾病中发挥重要作用. 某些信号通路的激活引发的神经炎症与抑郁症的发生有着密切的关系. 小胶质细胞是神经炎症的主要介导者，不同的刺激促进小胶质细胞极化，不同极化类型的小胶质细胞能分泌多种炎性细胞因子，在神经炎症调节中具有重要的作用. 临床研究和体内外实验研究表明，抑郁症与小胶质细胞极化介导的神经炎症有关. 小胶质细胞极化参与抑郁症发生发展的可能机制包括NF-κB信号通路激活、呼吸爆发、补体受体3信号通路、NLRP3炎症激活、cannibalism受体1、Notch-1信号通路和过氧化物酶体增殖物激活受体γ的激活. 本文就小胶质细胞极化与抑郁关系的研究进展作一综述.

    Abstract:

    Microglia mainly control the immune efficiency of the central nervous system and play an important role in various psychiatric diseases. Neuroinflammation triggered by the signaling pathway activation is related to the development of depression. Microglia are the main mediators of neuroinflammation. Different stimulations promote the polarization of microglia, which secrete inflammatory cytokines that affect the regulation of neuroinflammation. Clinical and experimental research in vivo and in vitro have demonstrated the relationship of depression with neuroinflammation mediated by microglial polarization. The possible mechanisms of polarization mediating depression involve NF-κB signaling pathway activation, respiratory bursts, complement receptor 3 (CR3) signaling pathway activation, NLRP3 inflammation activation, cannibalism receptor 1 (CB1) activation, Notch-1 signal pathway stimulation, and PPARγ receptor activation. This review discusses research progress on the relationship between microglial polarization and depression.

    参考文献
    相似文献
    引证文献
引用本文

万腾,高雪,刘顺峰,孟安娜,吕虹颖,吴颛,周寿红.小胶质细胞极化与抑郁症关系的研究进展[J].生物化学与生物物理进展,2021,48(12):1404-1413

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2021-07-10
  • 最后修改日期:2021-10-26
  • 接受日期:2021-11-09
  • 在线发布日期: 2021-12-23
  • 出版日期: 2021-12-20
  • 扫码关注

生物化学与生物物理进展 ® 2024 版权所有 ICP:京ICP备05023138号-1    京公网安备 11010502031771号