1)佛山科学技术学院物理与光电工程学院,佛山 528200;2)佛山科学技术学院机电工程与自动化学院,佛山 528200
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广东省科技计划(X200051UZ200)和广东省科技创新战略专项基金(pdjh2021a0520)资助项目。
1)School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China;2)School of Mechatronic Engineering and Automation, Foshan University, Foshan 528000, China
This work was supported by grants from Guangdong Science and Technology Plan (X200051UZ200) and Guangdong Science and Technology Innovation Strategy Special Fund (pdjh2021a0520).
目的 眼睛的光学生物参数中的眼轴长度(AL)和角膜曲率半径(CR)可以作为预防和监测眼球近视的两个重要参数。为了提高测量眼轴长度的速度与精度和同步实现角膜曲率高精度动态测量,本文提出一种基于低相干光干涉技术眼睛光学生物参数测量的系统。方法 该系统使用旋转光学延迟线快速改变参考光的光程,利用曲率半径为8 mm的标准件标定人眼角膜顶点到靶环之间的距离,利用角膜的干涉信号对相机和数据采集卡进行触发实现同步采集,从而实现眼轴长度的快速测量和精准定位靶环到角膜顶点之间的距离,同时保证成像系统的放大倍率恒定和数据的实时采集。结果 实验结果表明,这种低相干光干涉测量系统,可以实时测量眼轴长度和角膜曲率半径,眼轴长度误差低于40 μm,人眼角膜曲率半径方差为2.082 36×10-2 μm。结论 该系统能够快速、精准地测量AL和CR,可在近视的预防和监测中发挥重要作用。
Objective The axial length (AL) and the corneal curvature radius (CR) in the optical biological parameters of the eye can be used as two important parameters for the prevention and monitoring of ocular myopia. In order to improve the speed and accuracy of measuring the length of eye axis and to achieve high precision of corneal curvature simultaneously dynamic measurement, This paper proposes a system for measuring optical biological parameters of the eye based on low-coherence light interference technology.Methods The system uses a rotating optical delay line to quickly change the optical path of the reference light, and uses a standard part with a curvature radius of 8 mm to calibrate the vertex of the human cornea to the distance between the target ring and the interference signal of the cornea trigger the camera and the data acquisition card to achieve synchronous acquisition, thereby realizing rapid measurement of the axial length and precise positioning of the distance between the target ring and the corneal vertex, while ensuring the magnification of the imaging system constant and real-time data collection.Results Experimental results show that this low-coherence optical interferometry system can measure the axial length and corneal curvature radius in real time. The axial length error is less than 40 μm, and the human corneal curvature radius variance is 2.082 36×10-2 μm.Conclusion The system measures AL and CR quickly and accurately, which may play an important role in the prevention and monitoring of myopia.
胡积烨,陈隆,黄丽媛,丁文正,黄铭斌,张浩,曾亚光,谭海曙.基于低相干光干涉的眼睛光学生物参数测量研究[J].生物化学与生物物理进展,2022,49(9):1810-1820
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