Human have several senses, including vision, touch, hearing, taste, smell and taste, as well as temperature and pain. How organisms perceive the physical world has always attracted people to explore. Although new breakthroughs have been made in the discovery and research of different sensory receptors, the underlying molecular and cellular mechanisms of these sensation remain elusive. The 2021 Nobel Prize in physiology or medicine was awarded to David Julius and Ardem Patapoutian for their profound contributions to the discovery of temperature sensing and tactile receptors. For hearing research, although it won the Nobel Prize as early as 1961, the research on hearing receptors is still insufficient. This article review focuses on the discovery and research process of touch and hearing receptor NOMPC in invertebrate and hearing receptor TMC in mammalian. And this review also provides suggestions for the development of sensory perception in the future.