1)沈阳体育学院运动人体科学学院,沈阳 110102;2)上海体育学院运动科学学院,上海 200438;3)辽宁师范大学体育学院,大连 116029;4)沈阳体育学院运动与健康研究中心,沈阳 110115





国家自然科学基金(12072202) 资助项目。

Research Progress of Biological Functions of IL-27

1)School of Sports and Human Sciences, Shenyang Sport University, Shenyang 110102, China;2)School of Sports and Human Sciences, Shanghai Sport University, Shanghai 200438, China;3)School of Physical Education, Liaoning Normal University, Dalian 116029, China;4)Exercise and Health Research Center/Department of Kinesiology, Shenyang Sport University, Shenyang110115, China

Fund Project:

This work was supported by a grant from The National Natural Science Foundation of China (12072202).

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    白介素-27(interleukin-27,IL-27)是由p28亚基和Epstein-Barr病毒诱导的基因3(Epstein-Barr virus-induced gene 3,EBI3)构成的异源二聚体细胞因子。IL-27具有多重生物学功能,它通过激活下游Janus激酶信号转导/转录激活因子(Janus kinase signal transduction/transcriptional activator,JAK/STAT)、丝裂原活化蛋白激酶(mitogen activated protein kinases,MAPK)等信号参与调节机体免疫反应、细胞自噬、成骨细胞(osteoblast,OB)和破骨细胞(osteoclast,OC)分化等过程。最新研究证实其在促进脂肪细胞(adipocyte,AD)产热、提高胰岛素敏感性等方面同样具有重要作用。本文就IL-27的结构和生物学功能进行综述,旨在为IL-27的研究和应用提供参考。


    Interleukin-27 (IL-27) is a heterodimeric cytokine composed of p28 and Epstein-Barr virus-induced 3 (EBI3), which belongs to the IL-6/ IL-12 family group. IL-27 exerts its biological functions mainly by activating downstream signals such as Janus kinase signal transduction/transcriptional activator (JAK/STAT) and mitogen activated protein kinases (MAPK). Initially, IL-27 was considered to be an inflammatory factor with pro-inflammatory and anti-inflammatory effects. However, with the development of research in recent years, it has been confirmed that IL-27 plays a role in the body’s immunity and participates in osteogenesis and osteoclast differentiation, phagocytosis and improve insulin sensitivity. IL-27 mainly exerts immunosuppressive effects on CD4+ T cells, CD8+ T cells, and B cells. In CD4+ T cells, IL-27 has dual roles due to different stages of cell differentiation, local microenvironment changes, or activated downstream signals, e.g., IL-27 promotes Th1 cell differentiation in CD4+ T cells and can inhibit differentiation in a highly polarized state of Th1 cells. In CD8+ T cells, IL-27 promotes their proliferative activation and thus plays a role in the immune response and the efficacy of subunit vaccination. In B cells, due to different activation patterns and differentiation stages, IL-27 also has a dual role. It enhances the phosphorylation levels of STAT1 and STAT3 in naive B cells and promotes B cell proliferation; but in memory B cells, its effect is weakened and cannot promote B cell proliferation. In osteoblasts (OB) and osteoclasts (OC), IL-27 promotes OB differentiation mainly through Smad2/3 and STAT1, and inhibits OB differentiation through M-CSF/sRANKL in bone marrow-derived macrophage-like cells OC generation, thereby participating in the regulation of bone growth and remodeling. In addition, the latest research has confirmed that IL-27 can directly target adipocytes, promote adipocyte (AD) thermogenesis, and improve insulin sensitivity through the p38MAPK-PGC-1α signaling pathway, which also suggests that IL-27 plays an important role in metabolic great potential in disease. This article reviews the structure and biological function of IL-27, aiming to provide a reference for the research and application of IL-27.


李梦焕,杨旸,马迁鹤,衣雪洁,常波. IL-27生物学功能的研究进展[J].生物化学与生物物理进展,2023,50(1):67-77

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  • 收稿日期:2022-02-28
  • 最后修改日期:2022-11-29
  • 接受日期:2022-05-09
  • 在线发布日期: 2023-01-16
  • 出版日期: 2023-01-20