Objective In this study, we compared the control group and the Tai Chi exercise group to evaluate the rehabilitation effect of Tai Chi exercise on Parkinson’s disease patients in the early and middle stages.Methods Forty-five patients with Parkinson’s disease were randomly divided into a control group (n=15) who did not receive intervention, Tai Chi Group 1 (n=15) adopted 24-style simplified Tai Chi exercises, 40 min each time, 3 times a week, and Tai Chi Group 2 (n=15) adopted 24-style simplified Tai Chi exercises, 60 min each time, 3 times a week. At baseline, 12 weeks, and 24 weeks after exercise, patients were evaluated with Falls Efficacy Scale (FES), timed up-to-go test (TUGT), Berg Balance Scale (BBS), Unified Parkinson’s Disease Rating Scale (UPDRS) III scores, Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Pittsburgh sleep quality index (PSQI).Results In the Tai Chi 1 group, the improvement of TUGT and BBS scores at 24 weeks compared with the baseline was statistically significant (P<0.05). In Tai Chi 2 group, the improvement of TUGT and BBS scores was statistically significant (P<0.05) at 24 weeks compared with the baseline, and the improvement of TUGT was statistically significant at 24 weeks compared with 12 weeks (P<0.05).Conclusion Tai Chi exercise can improve the balance disorder and reduce the risk of falls in patients with Parkinson’s disease in the early and middle stages.