OSA严重度评估参数及诊断技术
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1.湖南师范大学工程与设计学院;2.湖南师范大学附属第一医院康复医学科

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国家自然科学基金


Severity Assessment Parameters and Diagnostic Technologies of Obstructive Sleep Apnea
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1.School of Engineering and Design,Hunan Normal University;2.Department of Rehabilitation Medicine,The First Affiliated Hospital of Hunan Normal University

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The National Natural Science Foundation of China

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    摘要:

    阻塞性睡眠呼吸暂停(OSA)是一种日益广泛的睡眠呼吸障碍性疾病,是很多高风险慢性疾病如高血压、冠心病、中风、心律不齐和糖尿病的独立危险因素,具有潜在的致命性。OSA防治的关键是早诊断、早治疗,因此OSA的评估与诊断技术成为研究热点。本文综述了OSA的严重度评估参数与诊断技术的研究进展,并探讨了未来发展的方向。在OSA严重度评估参数方面,呼吸暂停低通气指数(AHI)作为黄金标准,其与呼吸暂停低通气持续时间百分比(AH%)、最低氧饱和度(LSpO?)、心率变异性(HRV)、氧减指数(ODI)及新兴的生物标志物,共同构成了多维度评估体系。OSA诊断技术包括金标准多导睡眠监测(PSG)、便捷的家庭睡眠监测(HSAT)和心肺耦合(CPC)技术;而机器学习与人工智能作为新兴的诊断技术,由于其智能化和高准确度而日益受到青睐;此外标准化问卷和Epworth嗜睡评分(ESS)、影像学检查和声音检测技术也为OSA诊断提供了支持。关于未来发展方向,多模态融合、跨学科的整合研究、个性化诊疗模式的构建以及高新技术在临床应用中的推广将成为OSA评估与诊断领域的发展趋势。

    Abstract:

    Obstructive sleep apnea (OSA) is an increasingly widespread sleep-breathing disordered disease, and is an independent risk factor for many high-risk chronic diseases such as hypertension, coronary heart disease, stroke, arrhythmias and diabetes, which is potentially fatal. The key to the prevention and treatment of OSA is early diagnosis and treatment, so the assessment and diagnostic technologies of OSA have become a research hotspot. This paper reviews the research progresses of severity assessment parameters and diagnostic technologies of OSA, and discusses their future development trends. In terms of severity assessment parameters of OSA, apnea hypopnea index (AHI), as the gold standard, together with the percentage of duration of apnea hypopnea (AH%), lowest oxygen saturation (LSpO?), heart rate variability (HRV), oxygen desaturation index (ODI) and the emerging biomarkers, constitute a multi-dimensional evaluation system. Specifically, the AHI, which measures the frequency of sleep respiratory events per hour, does not fully reflect the patients' overall sleep quality or the extent of their daytime functional impairments. To address this limitation, the AH%, which measures the proportion of the entire sleep cycle affected by apneas and hypopneas, deepens our understanding of the impact on sleep quality. The LSpO? plays a critical role in highlighting the potential severe hypoxic episodes during sleep, while the HRV offers a different perspective by analyzing the fluctuations in heart rate thereby revealing the activity of the autonomic nervous system. The ODI provides a direct and objective measure of patients' nocturnal oxygenation stability by calculating the number of desaturation events per hour, and the biomarkers offers novel insights into the diagnosis and management of OSA, and fosters the development of more precise and tailored OSA therapeutic strategies. In terms of diagnostic techniques of OSA, the standardized questionnaire and Epworth sleepiness scale (ESS) is a simple and effective method for preliminary screening of OSA, and the polysomnography (PSG) which is based on recording multiple physiological signals stands for gold standard, but it has limitations of complex operations, high costs and inconvenience. As a convenient alternative, the home sleep apnea testing (HSAT) allows patients to monitor their sleep with simplified equipment in the comfort of their own homes, and the cardiopulmonary coupling (CPC) offers a minimal version that simply analyzes the electrocardiogram (ECG) signals. As an emerging diagnostic technology of OSA, machine learning (ML) and artificial intelligence (AI) adeptly pinpoint respiratory incidents and expose delicate physiological changes, thus casting new light on the diagnostic approach to OSA. In addition, imaging examination utilizes detailed visual representations of the airway's structure and assists in recognizing structural abnormalities that may result in obstructed airways, while sound monitoring technology records and analyzes snoring and breathing sounds to detect the condition subtly, and thus further expands our medical diagnostic toolkit. As for the future development directions, it can be predicted that interdisciplinary integrated researches, the construction of personalized diagnosis and treatment models, and the popularization of high-tech in clinical applications will become the development trends in the field of OSA evaluation and diagnosis.

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付卓志,吴亚岑,李媚希,尹平平,林海军,张 甫,杨宇祥. OSA严重度评估参数及诊断技术[J].生物化学与生物物理进展,,():

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  • 收稿日期:2024-05-16
  • 最后修改日期:2024-07-09
  • 接受日期:2024-07-11
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