不同运动对绝经后骨质疏松女性骨密度的影响——基于网状Meta分析的结果
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1)西北师范大学体育学院,兰州 730070;2)甘肃省中医院康复医学科,兰州 730070

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国家社会科学基金(21BTY078)和甘肃省基础研究计划-软科学专项(24JRZA065)资助。


Effect of Exercise Intervention on Bone Mineral Density in Postmenopausal Osteoporosis Woman ——a Network Meta-analysis
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Affiliation:

1)College of Physical Education, Northwest Normal University, Lanzhou 730070, China;2)Department of Rehabilitation Medicine, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730070, China

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This work was supported by grants from The National Social Science Foundation of China (21BTY078) and Gansu Province Basic Research Program-Special Funding for Soft Science (24JRZA065).

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    摘要:

    绝经后骨质疏松(postmenopausal osteoporosis,PMOP)是一种由雌激素水平下降引起的慢性代谢性骨病,随着人口老龄化进程的加速,其引发的公共卫生负担日趋严峻。运动作为防治骨质疏松的最佳非药物干预手段,能够全面改善肌肉-骨骼协同功能,调节内分泌和炎症微环境。但由于骨的机械适应性受雌激素水平的影响,现有的运动方案不能有效改善PMOP女性的骨密度。最有效的运动类型、剂量和个体化适配仍在不断地探索中。本文在充分考虑性别和激素水平差异性的基础上,检索并筛选PubMed、CNKI等数据库有关运动改善PMOP女性骨密度的随机对照试验,通过网状Meta分析系统回顾和比较不同类型运动方式对PMOP女性不同部位骨密度的影响,为探索最佳运动方式以维持或改善PMOP女性的骨密度提供理论指导。

    Abstract:

    Postmenopausal osteoporosis (PMOP) is a chronic metabolic bone disease caused by a decrease in estrogen levels. with the acceleration of population aging process, the public health burden caused by it is becoming increasingly severe. The prevalence rate of osteoporosis in people over 65 years old in China is as high as 32%, which is especially prominent after menopause, which is about 5 times that of elderly men. About 40% of postmenopausal women are at risk of osteoporotic fractures, with a disability rate of up to 50% and a fatality rate of about 20%. The prevention and treatment of osteoporosis has become a major public health issue of global concern, and it is particularly urgent to develop reasonable and effective prevention and treatment programs and explore their scientific basis. Exercise is an important non-drug means for the prevention and treatment of PMOP, it can improve estrogen levels and the expression of bone formation transcription factors, and inhibit the levels of proinflammatory factors and bone resorption markers, macroscopically manifested by the improvement of bone microstructure and bone density. However, the effectiveness of exercise in improving bone mineral density (BMD) remains controversial. Some studies revealed significant changes of bone to mechanical stimulation, while others showed no significant effect of mechanical training, this heterogeneity in bone adapt to mechanical stimulation is particularly evident in postmenopausal women. Although the evidence that a wide range of exercise programs can improve osteoporosis, the optimal solution to address bone mineral loss remains unclear. The most effective exercise type, dosage and personalized adaptation are still being determined. This study will fully consider the differences in gender and hormone levels, searching and screening randomized controlled trials of PubMed, CNKI and other databases regarding exercise improving bone mineral density in women with PMOP. Strictly following the PRISMA guidelines to reviewed and compared the effects of different types of exercise modalities on BMD at different sites in women with PMOP by network Meta-analysis, to provide theoretical guidance to maintain or improve BMD in women with PMOP.

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郝莹,杨宁宁,孙梦莹,周晓彬,陈卓.不同运动对绝经后骨质疏松女性骨密度的影响——基于网状Meta分析的结果[J].生物化学与生物物理进展,,():

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  • 收稿日期:2024-11-27
  • 最后修改日期:2025-04-10
  • 接受日期:2025-03-25
  • 在线发布日期: 2025-03-26
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