1.1)河北工业大学电气设备可靠性与智能化国家重点实验室,天津 300130;2.2)河北工业大学健康科学与生物医学工程学院,天津 300130;3.3)河北工业大学电气工程学院,天津 300130;4.4)河北工业大学天津市生物电磁技术与智能健康重点实验室,天津 300130;5.5)河北工业大学生物电磁与神经工程重点实验室 天津 300130;6.6)天津市环湖医院神经内科,天津 300202
国家重点研究发展计划,河北省自然科学基金,国家自然科学基金国际合作与交流基金的资助,天津市卫生健康科技计划,河北工业大学电气装备可靠性与智能化国家重点实验室
1.1)State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, China;2.2)School of Health Sciences & Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China;3.3)School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, China;4.4)Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, China;5.5)Key Laboratory of Bioelectromagnetics and Neuroengineering, Hebei University of Technology, Tianjin 300130, China;6.6)Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300202, China
the National Key R&D Program of China,the Natural Science Foundation of Hebei Province,the Funds for International Cooperation and Exchange of the National Natural Science Foundation of China ,Tianjin Health Science and Technology Program of China,State Key Laboratory of Reliability and Intelligence of Electrical Equipment of Hebei University of Technology of China
重复经颅磁刺激(rTMS)是一种有前景的非侵入性神经调节技术,可缓解阿尔茨海默病(AD)患者的认知和功能下降。本研究旨在利用临床量表、血液标记物和脑电图(EEG)数据,研究 rTMS 对 AD 患者神经振荡功率和脑功能网络(BFN)连接的影响。12名AD患者参与了实验,接受20Hz的rTMS 刺激。在刺激之前和之后获得临床评估、血液抗体检测和静息态脑电图记录。分析的重点是delta、theta、alpha、beta和gamma 频段的EEG功率,以及频率的BFN的构建,并评估网络特性。结果表明,rTMS后delta和theta功率显着降低(P<0.05),gamma功率显着增加(P<0.05),而 alpha 和 beta 功率没有显着变化(P>0.05)。此外,本研究还发现,刺激后,BFN在δ带的聚类系数显着降低(P<0.05),而全局效率增加(P<0.05)。在α波段,BFN程度显着增加(P<0.05),同时聚类系数和特征路径长度显着降低(P<0.05)。此外,临床量表评分、血液标记物和网络的拓扑属性之间存在相关性)。总体而言,这些研究结果表明,rTMS可以调节AD患者的δ、α和γ振荡强度,增强相应振荡网络的连通性,为临床量表、血液标志物和脑电图在AD患者中诊断和监测的应用价值提供了额外的证据。
Repetitive transcranial magnetic stimulation (rTMS) is a promising non-invasive neuroregulatory technique for alleviating cognitive and functional decline in patients with Alzheimer"s disease (AD). This study aimed to investigate the effects of rTMS on neural oscillation power and brain functional network (BFN) connectivity in AD patients, utilizing clinical scales, blood markers and electroencephalogram (EEG) data. Twelve patients with AD participated in the experiment, receiving rTMS stimulation at 20Hz. Clinical assessments, blood antibody detection, and resting-state EEG recordings were obtained both before and after stimulation. The analysis focused on the EEG power across delta, theta, alpha, beta, and gamma bands, and the construction of BFNs across these frequencies, with evaluation of network characteristics. Results indicated significant reductions in delta and theta powers following rTMS (P<0.05), a notable increase in gamma power (P<0.05), and no significant changes in alpha and beta power(P>0.05). In addition, this study revealed that after stimulation, the clustering coefficient of BFN in the delta band was significantly reduced (P<0.05), while global efficiency increased (P<0.05). In the alpha band, the degree of BFN increased significantly (P<0.05), alongside significant decreases in the clustering coefficient and characteristic path length (P<0.05). Furthermore, there was a correlation between clinical scale scores, blood markers and the topological attribute of the network.). Overall, these findings suggest that rTMS can modulate the intensity of delta, alpha, and gamma oscillations and enhance the connectivity of the corresponding oscillatory networks in AD patients, providing additional evidence for the application value of clinical scales, blood markers and EEG in in the diagnosis and monitoring of AD.
徐桂芝,刘琳,郭苗苗,王田,高娇娇,纪勇,王盼. rTMS对阿尔茨海默病认知功能与脑网络连接的调控效应[J].生物化学与生物物理进展,,():
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