1)天津大学医学工程与转化医学研究院,天津 300072;2)脑机交互与人机共融海河实验室,天津 300072;3)Swartz Center for Computational Neuroscience, University of California, San Diego, CA 92093, USA
国家重点研发计划(2023YFF1203705),国家自然科学基金(32541010,62406220,82472101)和天津市自然科学基金(23JCYBJC01440)资助项目。
1)Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China;2)Haihe Laboratory of Brain-computer Interaction and Human-machine Integration, Tianjin 300072, China;3)Swartz Center for Computational Neuroscience, University of California, San Diego, CA 92093, USA
This work was supported by grants from the National Key Research and Development Program of China (2023YFF1203705), The National Natural Science Foundation of China (62406220, 32541010, 82472101), and Tianjin Natural Science Foundation Project (23JCYBJC01440).
脑电图(electroencephalography,EEG)是一种无创、高时间分辨率的大脑皮层电生理活动监测技术,被广泛应用于临床诊断、脑机接口和认知科学等研究领域。然而,其信号幅值微弱(通常仅在微伏级别),极易受到眼电、心电、肌电、运动伪迹等各类噪声干扰。这些噪声不仅会掩盖真实的神经活动,还可能引入虚假特征,降低信号质量,严重影响EEG后续分析的准确性与可靠性。基于深度学习的EEG降噪技术通过学习受污染EEG与原始EEG之间的非线性映射,可实现对复杂伪迹噪声的自适应抑制与有效神经活动信息的保真重建。相比传统方法,该技术具有非线性建模能力强、对先验假设依赖性低以及网络架构适应性高等主要优势,有效提升EEG降噪性能,并在神经工程领域展现出重要的应用潜力。为厘清深度学习EEG降噪技术的研究与应用进展,本文从技术原理、基准数据集、降噪模型与评估方法4方面展开系统综述,并归纳其在神经信号解析与脑机接口解码中的典型应用,以期为该技术的深入研究与广泛应用提供方法论依据。
Electroencephalography (EEG) is a non-invasive neurophysiological monitoring technique. It records the electrical activity of the cerebral cortex using electrodes placed on the scalp surface. Owing to its high safety, portability, and millisecond-level temporal resolution, EEG has been widely utilized in a variety of fields, including clinical diagnosis, brain-computer interfaces (BCIs), and cognitive neuroscience research. However, due to its microvolt-level amplitude, EEG is highly susceptible to various artifacts, including electrooculographic (EOG), electrocardiographic (ECG), electromyographic (EMG), and power line interference (PLI). These artifacts can obscure genuine neural activity and introduce spurious electrophysiological features. Consequently, they may compromise EEG signal quality, thereby reducing the reliability of downstream analyses. To address this issue, numerous EEG artifact removal methods have been developed, including both traditional denoising techniques and deep learning-based approaches. Traditional EEG denoising methods have long served as the primary solutions for artifact removal. Representative approaches include filtering, regression, and blind source separation. Although these methods have demonstrated effectiveness in specific scenarios, they suffer from several inherent limitations. Filtering assumes that artifacts and EEG signals can be separated in the frequency domain, but many artifacts, such as EOG and EMG, overlap with EEG spectra, which may lead to the loss of valuable neural information. Regression methods require high-quality artifact references to estimate and subtract contaminations, limiting their effectiveness in reference-free scenarios. Blind source separation can remove artifacts without external references, but it typically requires the number of EEG channels to exceed the number of sources, restricting its application in single- or low-channel EEG recordings. Deep learning-based EEG denoising methods address these limitations effectively. First, they learn the nonlinear mapping between contaminated and clean EEG directly from data in an end-to-end manner. This approach does not rely on assumptions about spectral separability, thereby preserving neural activity more completely. Second, the reference information is incorporated during the training phase, allowing the trained model to perform artifact removal independently without external references. Third, deep learning models can be flexibly designed to accommodate various recording setups, achieving robust denoising for both high-density and single-channel EEG. Collectively, these advantages enable deep learning-based methods to overcome the main challenges of traditional approaches, providing more accurate and reliable EEG signal recovery. The superior denoising performance of deep learning-based EEG denoising methods has attracted increasing attention in EEG artifact removal research. As a result, many deep learning-based denoising methods have been developed and successfully applied in neural engineering areas. However, a systematic review of the techniques and applications in this field is still lacking. To address this gap, this paper reviews recent advances in deep learning-based EEG denoising from four perspectives: technical principle, benchmark dataset, denoising model, and evaluation method. Representative applications in neural signal analysis and BCI decoding are also summarized. Furthermore, the advantage, existing challenge, and future research direction of deep learning-based EEG denoising are discussed. This review aims to provide valuable theoretical insights and technical guidance for researchers. It is also expected to promote further advances and broader applications of deep learning-based EEG denoising techniques.
单宝莲,于海情,黄永志,孟佳圆,许敏鹏,钟子平,明东.基于深度学习的脑电降噪技术及应用[J].生物化学与生物物理进展,2026,53(8):2147-2160 SHAN Bao-Lian, YU Hai-Qing, HUANG Yong-Zhi, MENG Jia-Yuan, XU Min-Peng, JUNG Tzyy-Ping, MING Dong. Technique and Application of Deep Learning-based EEG Denoising[J]. Progress in Biochemistry and Biophysics,2026,53(8):2147-2160
复制

扫码关注 生物化学与生物物理进展 ® 2026 网站版权 ICP:京ICP备05023138号-1 京公网安备 11010502031771号
