The cell electrophoresis and dielectrophoresis of the erythrocytes in rabbits with hypercholesterolemia were measured. The results ihdicated that the aggregation of these erythrocytes was inereased, while thier deformation and membrane fluidity were decreased compared with the control. It suggests that the hypercholesterolemia may be one of the reasons which causes the thrombosis. The results also showed that 8501 (the effective principle of the chinese herb) could regulate above changes of the erythrocytes, which implied that 8501 may have benefit in preventing and treating thrombosis and atherosclerosis.