Antagonistic Effect of Benzylisoquine Compound D<sub>20</sub> on CaM Activating Phosphodiesterase

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Antagonistic Effect of Benzylisoquine Compound D20 on CaM Activating Phosphodiesterase
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Abstract:

Synthetic benzylisoquine compound D₂₀ exibites stronger inhibition on CaM-activatedphosphodiesterase than TFP.IC₅₀=5μmol/L.Flourescence analysis indicats that the asso-ciation constant (K_a) for the interaction between CaM and compound D₂₀ is 2.64(μmol/L)^-1 and compound D₂₀ molecule possesses 2 binding sites for CaM.Binding style is discussed.

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Zhang Yuan, Hu Zhuoyi, Zhao Ye, Cai Huimin. Antagonistic Effect of Benzylisoquine Compound D₂₀ on CaM Activating Phosphodiesterase[J]. Progress in Biochemistry and Biophysics,1993,20(1):28-32

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Received:September 25,1991
Revised:February 22,1992
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