The recent results in the research of gene therapy have been encouraging,in spite of numerous problems still remaining to be solved.The basic studies on gene therapy and the study on the techniques of the gene introduction are reviewed.The latter is one of the most important topics in basic studies, including retrovirus vectors,DNA virus vectors as well as non-viral techniques.The recent advances in the establishment of the experimental models are also described.Then the recent advances in the gene therapy of hereditary diseases, malignant tumors and other diseases are briefly discussed, especially emphasizing the strategies of the gene therapy of AIDS and cardiovascular diseases.