Pyrophosphate:fructose-6-phosphate 1-phosphotransferase (PFP) catalyzes the reversible conversion of fructose-6-phosphate and fructose-1,6-bisphosphate,The enzyme generally exists in kinds of higher plants and some of microorganisms.Some advance in the research of PFP after 1990 was reviewed.It contains the types and the constitution of subunits,the active center,the substrate specificity,the regulation of activity and the fuction of PFP.