The experimental results show that chemotaxis and adherence of polymorphonuclear neutrophil(PMN)are promoted obviously by exogenous phospholipase A2 and calcium ionophore(A23187). Furthermore,for the PLA2 inhibitor p-bromophenacyl bromide(PBPB) and the PLA2 antibody, the inhibitory effect on PLA2-induced PMN chemotaxis and adherence is concentration dependent but they have no effect on A23187-induced PMN chemotaxis and adherence. This result indicates that PLA2 induced chemotaxis and adherence of PMN may be inhibited by direct interaction between PLA2 and PBPB or PLA2 antibody. A23187 induced PMN chemotaxis and adherence is different from that induced by PLA2.