Two questions on iron metabolism in reticulocyte are deliberated. Firstly, how does reticulocyte acquire transferrin-bound iron? The current knowledge on transferrin-bound iron uptake by reticulocyte, a seven stepwise process, is summarized. Secondly, how does iron cross the endosome membrane in reticulocyte after it is released from transferrin? Some relevant hypotheses including membrane iron channel, iron carrier-mediated transport, the involvement of H^＋-ATPase, MIP system and function of free radical reactions in the process are discussed. Finally, some important aspects for further investigation are suggested.