Vascular endothelial growth factor receptors are the membrane-spanning receptors which were found in vascular endothelial cells and induce the proliferation and differentiaion of endothelial cells. There are two receptors which can specially bind with VEGF. They are Flt and KDR, the gene structures and locations in the chromosome of flt and KDR were identified. Both Flt and KDR are receptors of type Ⅲ RTKs. Their structures are similar. There are seven immunoglobin-like sequence in extracellular domain. The catalytic domains in intracellular region were inserted by tyrosine kinase domains. Autophosphorylation was induced, which results in intracellular response. The VEGF repeptors play an important role in angiovascular, wound repair, inflammatory response, tumour growth and some cardiovascular diseases.