On the basis of the transition-state theory, catalytic antibodies could be induced in body by using a transition-state analogue as hapten which was selected according to the specific reaction mechanism. A fuller description is given on the principle of hapten design for generation of catalytic antibodies, the relationship between catalytic antibodies and non-catalytic antibodies and the comparison of catalytic antibodies with enzymes. The application prospects of catalytic antibody in medicine science and the limitations in the application are also discussed.