Promotive Effect of Superoxide and Inhibitory Effect of EBSELEN on Glutamate Binding to Rat Cortical Synaptosomal Membranes

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Promotive Effect of Superoxide and Inhibitory Effect of EBSELEN on Glutamate Binding to Rat Cortical Synaptosomal Membranes
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Promotive effect of superoxide and inhibitory effect of EBSELEN on ［³H］DL-glutamate binding to rat cortical synaptosomal membranes were studied by radiolabeled receptor assay. O^{^-_·}₂ results in a marked increase of specific glutamate binding. EBSELEN (1 μmol/L ) shows an inhibition effect on glutamate binding influenced by O^{^-_·}₂.

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YI Yong, YANG Xiangliang, ZHAO Xilong, ZHANG Hengshan, QIN Yuhui, XU Huibi. Promotive Effect of Superoxide and Inhibitory Effect of EBSELEN on Glutamate Binding to Rat Cortical Synaptosomal Membranes[J]. Progress in Biochemistry and Biophysics,1997,24(6):537-539

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Received:October 30,1996
Revised:March 05,1997
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