Recent years the structural biology have been developing very fast and growing into a new phase. The rate of determination of biomacromolecular structure has been reached to 5.1/day and goes up as an exponential curve. To the date of April '98, the released coordinates from PDB have been 7 454. Meanwhile the structure research combines with the functional research to gain insight into mechanisms of many biological process. The application of the third generation synchrotron radiation has greatly impact on X-ray crystal structure determination. With very bright X-ray from the synchrotron, one can start from very small crystals and gain a big structure, and also detect the instantaneous change of structure in time scale of 10^－9 s. It therefore may open the door for the structure determination of membrane proteins and large complex and assembly as nucleosome core particle. The molecular weight of solution structure determined by NMR has beyond 35 000. Now the structural biology is marrying with the genomics to produce a new “big science”, the structural genomics, which will provide a large step towards the understanding of life in the postgenomic ear.