As a translator factor, CREB takes part in the transformation process from short term memory to long term memory, which has been evidenced in several different kinds of animals. In addition, its two forms as both activator and inhibitor with high conservation in their gene structures can mediate this transformation process in a more precise manner. Researches having been conducted so far and the recent progressed in this field were reviewed; the issues to be researched and addressed in future were also pointed out.