Extra cellular matrix (ECM) is a dynamic reticular structure, which distributes among cell spaces. The structural proteins of ECM are varied and include collagens, proteoglycans, multidomain glycoproteins and other biomacromolecules. These proteins can combine with the specific receptors which exist on the surface of cells. This will result in different gene expression by connecting with intracellular skeleton frame directly or initiating signal transduction cascades, and lead to cells proliferation and differentiation. Matrix Metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in the process of ECM destruction and remodeling. MMPs is also a Zn²⁺ dependant proteolytic enzyme. MMPs expression is regulated strictly by growth factors, cytokines, and hormones at transcription level, by their natural activators and inhibitors at protein level. MMP participate various cells physiological and pathological process by degrading different ECM components.