The SIP technology is achieved by exploring the modular structure of minor coat protein Ⅲ of filamentous phage, and based on the technique of phage display. In SIP, the infectivity of an otherwise non-infective phage particle is restored strictly upon the binding occurrence between interacting molecular partners. Some mechanistic dissection studies showed that SIP is a novel extremely effective and highly specific technique for identifying interacting molecular pairs, and it is very promising.