Synucleins, as a family of small proteins enriched in presynaptic element in CNS, share a secondary structure feature of periodicity of amphipathic α-helix with 11 amino acid residues throughout the N-terminus. The physiological function of synucleins is unknown, but large quantities of research suggest that synucleins may be implicated in synaptic genesis and plasticity. Also, the relations of synuleins to many neurodegenerative diseases such as Alzheimer's and Parkinson's as well as to the invasion of breast cancer have been gaining attention of researchers.