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bcl-x Gene and Its Regulation on Apoptosis
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    Abstract:

    bcl-x gene is an important member of the bcl-2 multigene family.Three isoforms:Bcl-XL,Bcl-XS and Bcl-Xγ,are generated by alternative splicing.Bcl-XL and Bcl-Xγ inhibit apoptosis. However,Bcl-XS enhances apoptosis. Bcl-x plays a role in cell development,homeostatic balance, tumorigenesis and prognosis, which regulates apoptosis through interacting with Bcl-2, Bax, Bad and so on.

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CHEN Yang-Chao, ZHOU Ke-Yuan. bcl-x Gene and Its Regulation on Apoptosis[J]. Progress in Biochemistry and Biophysics,1999,26(6):534-536

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History
  • Received:October 21,1998
  • Revised:January 07,1999
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