Recently lot of research indicated that pluripotent neural stem cells with self-renewal and multilineage potential are present in the adult mammalian forebrain. The forebrain tissue containing persistent neural stem cells is referred to as “brain marrow”, since it has much in common with hematopoietic bone marrow. Neuropoiesis are very important field in neuroscience. A thorough investigation of neuropoiesis in the brain marrow should facilitate utilizing of migrating neurons in the adult human forebrain and transplanting human ES cells to treat neurodegeneraton diseases.