Ultra-weak chemiluminescence analytical technology has been developed rapidly in recent years. The technique in pharmaceutical analysis was introduced by using two examples. One is based on the chemiluminescence reaction of Ce(Ⅳ)-analgin-rhodamine 6G and the other is based on the auto-oxidation of analgin in micellar medium. An ultra-weak chemiluminescence analyzer has been coupled to flow-injection device for the determinations.