Great efforts have been done to reveal the secretary pathway of protein in the recent years. And RTN (reticulon) is a gene family localized on the membrane of endoplasmic reticulum. Up to now RTN1,RTN2,RTN3,RTN4 in this family have been found. While further studies to dissect the concrete function of these genes in the protein secretary pathway and to identify the RTN1 as a marker of specificity of neuroendocrine secretion and its relation to the differentiation of neurons have been doing.