Signal transduction of reactive oxygen species (ROS) has been of great interest recent years. ROS may signal through oxidation or reducton of specific groups such as cystein residues or redox-active iron center on certain biomolecules, or through modulating cellular redox status in different cell types. There were many documents indicating that signal pathway of ROS associate with some well-known regulating molecules as following: protein tyrosine kinase (PTK), protein kinase C (PKC), mitogen activated protein kinase (MAPK), nuclear factor NF-κB, AP-1 and Ca^2＋ ,cGMP. Although great advances of signal transduction of reactive oxygen species has been taken in recent years，there are many important questions remained to be answer in future.