There exists a special kind protein, lacking intrinsic enzymatic activity, in signal transduction system, termed scaffold protein. It has ability of binding two or more proteins simultaneously. It permits signal transduction in a specific and efficient manner by binding functionally related proteins into a signalosome.
Ni Fu-Tai, Li Yong. Scaffold Protein: the Molecular Glue in Signal Transduction[J]. Progress in Biochemistry and Biophysics,2001,28(4):470-473
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