Search for Differentially Expressed Proteins Involved in the Treatment of Human Nasopharyngeal Carcinoma Cells with NGX6 Using Two-dimensional Electrophoresis and Mass Spectrometry

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Search for Differentially Expressed Proteins Involved in the Treatment of Human Nasopharyngeal Carcinoma Cells with NGX6 Using Two-dimensional Electrophoresis and Mass Spectrometry
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Fund Project:This work was supported by grants from the National “863” Project of China (102-10-01-05) and National Natural Science Foundation of China (39900163 & 3000096).

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Abstract:

The current study was designed to reveal the preliminary function of NGX6 to NPC cells. In search of mechanisms of NGX6 2-D PAGE was used to identify proteins that were overexpressed in HNE cells that were transfected with NGX6. After staining and image analysis, spots of interest were isolated and subjected to mass spectrometry. Seven proteins such as Fas,ZNF and MHC-ⅡAg were identified. The possible significance of these findings is discussed. NGX6 may exert its effect on NPC cells by many ways.

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LI Jiang, TAN Chen, XIANG Qiu, ZHANG Xiao-Mei, MA Jian, LI Wei-Fang, WANG Jie-Ru, YANG Jian-Bo, LIANG Song-Ping, LI Gui-Yuan. Search for Differentially Expressed Proteins Involved in the Treatment of Human Nasopharyngeal Carcinoma Cells with NGX6 Using Two-dimensional Electrophoresis and Mass Spectrometry[J]. Progress in Biochemistry and Biophysics,2001,28(4):573-578

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Received:January 18,2001
Revised:April 05,2001
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